Cold exposure leads to ice crystal formation, cellular dehydration, protein denaturation, inhibition of DNA synthesis, abnormal cell wall permeability with resultant osmotic changes, damage to capillaries, and pH changes. Rewarming causes cell swelling, erythrocyte and platelet aggregation, endothelial cell damage, thrombosis, tissue edema, increased compartment space pressure, bleb formation, localized ischemia, and tissue death.
26.12.10
Cold exposure leads to ice crystal formation, cellular dehydration, protein denaturation, inhibition of DNA synthesis, abnormal cell wall permeability with resultant osmotic changes, damage to capillaries, and pH changes. Rewarming causes cell swelling, erythrocyte and platelet aggregation, endothelial cell damage, thrombosis, tissue edema, increased compartment space pressure, bleb formation, localized ischemia, and tissue death.
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